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These choices will be signaled globally to our partners and will not affect browsing data. We and our partners process data to: Actively scan device characteristics for identification. I Accept Show Purposes. Was this page helpful? Thanks for your feedback! The interaction with the pathogen can be direct, through recognition of pathogen-associated molecular patterns PAMPs by neutrophil pattern recognition receptors PRRs , or indirect, through recognition of opsonised microbes by Fc receptors or complement receptors.
The phagosome undergoes a rapid maturation process that involves the fusion with neutrophil granules and the targeted delivery of antimicrobial molecules and generation of reactive oxygen species ROS.
Degranulation of specific granules on the neutrophil surface and the extrusion of nucleic acids to form neutrophil extracellular traps NETs create an antimicrobial milieu at the inflammatory site and contributes to killing of extracellular pathogens.
Neutrophils at the interface between innate and adaptive immunity Neutrophils have historically been viewed as short-lived effector cells of the innate immune system as they undergo spontaneous apoptosis in vitro unless rescued by survival signals such as inflammatory cytokines or microbial compounds Figure 1, left. However, this view rarely takes into account the notion that neutrophils make important contributions to the recruitment, activation and programming of other immune cells.
Recent studies demonstrate that neutrophils themselves secrete an array of pro-inflammatory and immunomodulatory cytokines and chemokines capable of enhancing the recruitment and effector functions of other cells.
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